After an automatic windows 10 update and reboot, , I received the following similar error - but it did not give any details. This is exactly what it said:
"Unable to communicate with the WSJT-X process.
UDP Port :
IP Address :
Values read from WSJT-X config file...
WSJT-X Detected Instance...
Process Window Title :
Process Command Line :
Decode alerts and logging will be unavailable until corrected."--
I was running JTAlert 2.50.0 and WSJT-X 2.3.1. I decided to update WSJT-X to 2.4.0 and it worked fine after that. I did not change any UDP settings or anything else. I did not even reboot the PC after updating WSJT-X. I am using the standard recommended UDP ports in my settings. Hope this helps. You might want to try downgrading to 2.4.0 and see what happens.